一、基本信息
刘志华，博士，教授，博士生导师
电子邮件：Zhihua_Liu(AT)hubu.edu.cn
研究领域：
本课题组专注于探究睡眠与昼夜节律行为背后的神经生物学机制，致力于从多个层面揭示其调控网络以及在生理和病理方面的重要意义。我们运用前沿技术，结合跨学科方法，对以下关键问题展开系统性研究：
1. 睡眠调控的神经环路与分子机制：深入解析睡眠是如何通过神经环路和分子机制进行调控的。具体包括睡眠时长、睡眠需求、睡眠质量以及入睡速度等方面，试图弄清楚是什么在大脑中控制着我们的睡眠状态。
2. 代谢节律与摄食行为的时空调控：研究代谢节律和摄食行为在时间维度上的调控规律。探索节律紊乱会带来哪些影响，不同组织之间如何就代谢和摄食进行沟通，以及背后的分子机制是怎样的。
3. 神经环路的发育组装与可塑性：关注睡眠和节律相关神经网络在发育过程中的组装方式，以及这些神经环路如何随着时间发生可塑性变化。
二、教育背景
2004.09–2011.07 中国科学院遗传与发育生物学研究所，发育生物学博士
2000.09–2004.07 兰州大学，理学学士
三、工作经历
2021.05至今 太阳成tyc33455cc生命科学院，教授
2013.2–2021.04 美国哈佛大学医学院神经生物学系，博士后
2011.08–2013.01 中国科学院遗传与发育生物学研究所，博士后
四、社会任职
中国细胞生物学会生物节律分会委员、湖北省细胞生物学会理事、Science Advances, Journal of Neuroscience, Journal of Genetics and Genomics, PLOS One, Neuroscience Bulletin, NeuroMolecular Medicine, BMC Neuroscience 等审稿人。
四、代表性论文（#第一作者; *通讯作者）
● Liu, Z., Xie, D., Zhang, S.X. et al. Behavioral adaptation to warm conditions via Lim1-mediated acceleration of neuronal clocks. Nat Neurosci 29, 374–386 (2026). https://doi.org/10.1038/s41593-025-02139-2. [本文揭示了动物在高温环境下通过加速生物钟神经元的振荡节律来调整日常行为模式的神经环路与分子机制。]
● Zeeshan, M., Hu, J., Mao, C.-X., Danish, A., Xiong*, Y., Irshad*, M. S., Dao, V.-D.*, & Liu, Z.* (2025). Nanomaterial-enabled drug delivery systems for circadian medicine: Bridging direct rhythm modulation and chronotherapy. RSC Advances, 15(38), 31981–32008. https://doi.org/10.1039/D5RA04137F [本文系统综述了纳米材料介导的药物递送系统在昼夜节律医学中的应用前景，涵盖直接调控生物节律与优化药物给药时间窗口两个方向的研究进展，并讨论了该领域尚待解决的关键问题。]
● Wang, J., Chang, J., Wang, K., Liang, B., Zhu, Y., Liu, Z., Liang, X., Chen, J., Peng, Y., Agnarsson, I., others, 2025. Blue light restores functional circadian clocks in eyeless cave spiders. Science Advances 11, eadr2802. [本文发现蓝光能够在失去眼睛的洞穴蜘蛛中恢复功能性昼夜节律，揭示了独立于视觉系统的光感受通路在生物钟调控中的保守作用。]
● Hu, J., Bi, R., Luo, Y., Wu, K., Jin, S., Liu, Z., Jia, Y., Mao, C.-X., 2025. The gut microbiome promotes locomotion of Drosophila larvae via octopamine signaling. Insect Science 32, 277–289. [本文揭示了肠道共生微生物通过调节宿主体内特定神经递质的信号传导来促进果蝇幼虫的运动行为，为在机制层面理解肠道菌群与神经系统的功能互作提供了新证据。]
● Zhou, B., Feng C., Sun S., Chen X., Zhuansun D., Wang D., Yu X., Meng X., Xiao J., Wu L., Wang J., Wang J., Chen K., Li Z., You J., Mao H., Yang S., Zhang J., Jiao C., Li Z., Yu D., Wu X., Zhu T., Yang J., Xiang L., Liu J., Chai T., Shen J., Mao C., Hu J., Hao X., Xiong B., Zheng S., Liu Z.,*, Feng J.* (2024) Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos. Developmental Cell. 10.1016/j.devcel.2024.03.034. [本文利用单细胞转录组测序技术，解析了小鼠胚胎肠神经系统发育过程中位于迁移前沿的神经嵴干细胞亚群的分子特征，并鉴定了指定该细胞亚群命运的关键信号通路。]
● Zhang, S., Wang, X., Liu, Z., Jin, S., Mao, C.-X., 2023. Using Drosophila Larval Neuromuscular Junction and Muscle Cells to Visualize Microtubule Network. Journal of Visualized Experiments (JoVE) e65774. [本文建立并详细展示了一套利用果蝇幼虫神经肌肉接头和肌肉细胞原位观察微管网络结构的可视化实验方法。]
● Niu, X., Mao, C.-X., Wang, S., Wang, X., Zhang, Y., Hu, J., Bi, R., Liu, Z.*, Shan, J.*, 2023. α-Tubulin acetylation at lysine 40 regulates dendritic arborization and larval locomotion by promoting microtubule stability in Drosophila. PLoS One 18, e0280573. [本文发现微管蛋白的乙酰化修饰通过增强微管结构的稳定性来调控神经元树突的分支形态与动物运动行为，揭示了蛋白质翻译后修饰在神经发育中的重要调控功能。]
● Gu L, Wang L, Chen H, Hong J, Shen Z, Dhall A, Lao T, Liu C, Wang Z, Xu Y, Tang HW, Chakraborty D, Chen J, Liu Z, Rogulja D, Perrimon N, Wu H, Shi Y. (2020) CG14906 (mettl4) mediates m(6)A methylation of U2 snRNA in Drosophila. Cell Discovery 6, 44.
● Huang, Y., Huang, S., Lam, S.M., Liu, Z., Shui, G., Zhang, Y.Q., 2016. Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids. Journal of Cell Science 129, 4034–4045.
● Liu, Z.#, Huang, Y., Hu, W., Huang, S., Wang, Q., Han, J., Zhang, Y.Q., 2014. dAcsl, the Drosophila ortholog of acyl-CoA synthetase long-chain family member 3 and 4, inhibits synapse growth by attenuating bone morphogenetic protein signaling via endocytic recycling. Journal of Neuroscience 34, 2785–2796.
● Graf, E.R., Valakh, V., Wright, C.M., Wu, C., Liu, Z., Zhang, Y.Q., DiAntonio, A., 2012. RIM promotes calcium channel accumulation at active zones of the Drosophila neuromuscular junction. Journal of Neuroscience 32, 16586–16596.
● Yao, A., Jin, S., Li, X., Liu, Z., Ma, X., Tang, J., Zhang, Y.Q., 2011. Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria. Human Molecular Genetics 20, 51–63.
● Liu, Z.#, Huang, Y., Zhang, Y., Chen, D., Zhang, Y.Q., 2011. Drosophila Acyl-CoA synthetase long-chain family member 4 regulates axonal transport of synaptic vesicles and is required for synaptic development and transmission. Journal of Neuroscience 31, 2052–2063.
● Jin, S., Pan, L., Liu, Z., Wang, Q., Xu, Z., Zhang, Y.Q., 2009. Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation. Development 136, 1571–81.
● Reeve, S.P., Lin, X., Sahin, B.H., Jiang, F., Yao, A., Liu, Z., Zhi, H., Broadie, K., Li, W., Giangrande, A., others, 2008. Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP. Journal of Neuroscience 28, 3221–3226.
