2025

1. Xiayu Li, Yanping Zhang, Xiaotong Chen, Yuxin Zhang, Owais Khan, Letian Xu. (2025) Gut microbiota variation drives differential performance in leaf beetles across host plants. Microbiome. https://doi.org/10.1186/s40168-025-02278-5

2. Anxiang Wang, Tian Meng, Ju Wang, Xiaomei Xu, Dan Li, Zhanqing Lv, Aiqi Yan, Mian Zhou, Bo Ding, Qiu Yang. (2025) Stabilisation of tomato yellow leaf curl china virus infectious clones through micro-homology mediated end joining. Plant Biotechnology Journal. https://doi.org/10.1111/pbi.70455

3. Ce Shi, Zifu Zhao, Yicheng Zhong, Xingchun Tang, Pan Luo, Meng-Xiang Sun. (2025) Reprogramming of microspore fate via BBM-BAR1 for highly efficient in vivo haploid induction. Cell. https://doi.org/ 10.1016/j.cell.2025.08.014

4. Ling Wang, Ying Wang, Xiaogang Peng, Chenghua Gao, Xinfang Wei, Peng Chen, Pan Xiao, Qian Li, Aitao Li. (2025) Divergent evolution of fungal P450 monooxygenase unlocks simultaneous access to C12β and C15α oxyfunctionalization of steroids. Nature Communications. https://doi.org/10.1038/s41467-025-65736-6

5. Qing Zhang, Shisi He, Zhihao Zhu, Fangzhou Cheng, Yaping Jin, Wangying Zhu, Fan Yang, Yaozhong Chen, Mengyuan Zhang, Xin Li, Dongbo Cai, Shouwen Chen. (2025) Unraveling the chrono-regulatory function of PhoP in nitrogen metabolism: A multi-scale engineering framework aimed at optimizing the synthesis of poly-γ-glutamic acid in Bacillus licheniformis. Chemical Engineering Journal. https://doi.org/10.1016/j.cej.2025.165782

6. Fei Wang, Huiqi Sun, Di Deng, Yuanqing Wu, Jing Zhao, Qian Li, Aitao Li. (2025) Multidimensional engineering of Escherichia coli for efficient adipic acid synthesis from cyclohexane. Advanced Science. https://doi.org/10.1002/advs.202411938

7. Zhulong Hu, Ziqian Li, Yu Wang, Yiling Luo, Wanping Guo, Ning Meng, Guolong Bu, Lele Zhang, Shuxin Li, Xiangwei Kong, Xinyan Fang, Qiaoli Wang, Runkun Han, Zheng Zhao, Gexin Zhao, Ziying Jiang, Runxian Jin, Musheng Zeng, Qian Zhong. (2025) Extracellular vesicles derived EBV tegument protein BRRF2 suppresses cGAS phase separation to promote anti-viral innate immune evasion. Nature Communications. https://doi.org/10.1038/s41467-025-64037-2

8. Wu H, Lu Z, Yang Y, Pan R, Zhang Z, Yao X, Zhai Z, Li X, Wu G, Zhai C, Gao H. (2025) dPAFS: A nuclease-dead PfAgo-mediated fluorescence sensing platform for genotyping genome-edited rice. Biosens Bioelectron. https://doi.org/10.1016/j.bios.2025.117364

9. Guobao Li, Tianjiao Du, Jiening Wang, Kaiyue Jie, Zhuolu Ren, Xiaokang Zhang, Long Zhang, Shan Wu, Heng Ru. (2025) Structural insights into the RNA-dependent RNA polymerase complexes from highly pathogenic Marburg and Ebola viruses. Nature Communications. https://doi.org/10.1038/s41467-025-58308-1

10. Yunfan Xu, Shuopeng Qi, Gongrui Zhang, Dan Liu, Dejin Xu, Tong Qin, Qin Cheng,Han Kang, Bei Hu, Zhen Huang. (2025) One-pot ligation of multiple mRNA fragments on dsDNA splint advancing regional modification and translation. Nucleic Acids Research. https://doi.org/10.1093/nar/gkae1280

11. Juanjuan Feng, Xuanzheng Xiao, Xinting Xia, Jian Min, Weiying Tang, Xinyi Shi, Ke Xu, Guizhen Zhou, Kangkang Li, Panpan Shen, Rujuan Bao, Shuyao Wu, Mengjia Lin, Kun Yuan, Zhengke Lian, Xiaotong Zhai, Jun Wu, Chunyong Ding, Huixin Zhao, Xinqi Gong, Sulin Zhang, Jianping Jin, Dali Li, Mingyao Liu, Youqiong Ye, Buyong Ma, Rey-Ting Guo, Ao Zhang, Xiufeng Pang (2025) A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers, Cancer Cell. https://doi.org/10.1016/j.ccell.2025.07.006

12. Yitong Li, Yunyun Yang, Mengting Zhang, Xiaoping Yue, Rey-Ting Guo, Zedu Huang, Fener Chen. (2025) Mutagenesis of a single site inverts the stereopreference of imine reductase. ACS Catalysis. https://doi.org/10.1021/acscatal.5c00046 14

13. Chun-Chi Chen, Zhi-Pu Yu, Ziwei Liu, Yongpeng Yao, Peter-Leon Hagedoorn, Rob Alexander Schmitz, Lujia Yang, Lu Yu, Aokun Liu, Xiang Sheng, Hao Su, Yaqing Ma, Te Wang, Jian-Wen Huang, Lilan Zhang, Juzhang Yan, Jinping Bao, Chengsen Cui, Xian Li, Panpan Shen, Wuyuan Zhang, Jian Min, Chang-Yun Wang, Rey-Ting Guo, Shu-Shan Gao. (2025) Chanoclavine synthase operates by an NADPH-independent superoxide mechanism. Nature. https://doi.org/10.1038/s41586-025-08670-3 15

14. Jie Qiao, Junqi Zhang, Qingyuan Jiang, Shuqi Jin, Ruyi He, Bin Qiao, Yi Liu. (2025) Boosting CRISPR/Cas12a intrinsic RNA detection capability through pseudo hybrid DNA–RNA substrate design. Nucleic Acids Research. https://doi.org/10.1093/nar/gkaf510

15. Panpan Shen, Xinyu Lu, Caihong Wang, Jian Min, Jian-Wen Huang, Junjie Luo, Yushun Sun, Chun-Chi Chen, Rey-Ting Guo. (2025) Structural and mechanistic investigations of a high-fidelity Cas9 from Parasutterella secunda. ACS Catalysis. https://doi.org/10.1021/acscatal.5c02993

16. Zhenzhen Xie, Lilan Zhang, Qiru Li, Jian-Wen Huang, Yanting He, Hualin Zhang, Xinyue Wang, Jian Min, Chun-Chi Chen, Rey-Ting Guo. (2025) Apramycin Biosynthesis: Structure and mechanism of action of a new-type transaldolase AprG from Streptoalloteichus tenebrarius. ACS Catalysis. https://doi.org/10.1021/acscatal.5c02753

17. .Rao, Y., Wang, J., Zhao, R., Zhan, Y., Ma, X., He, P., Chen, S. (2025). Efficient sustainable production of protocatechuic acid from glucose by engineered Bacillus licheniformis. Chemical Engineering Journal. https://doi.org/10.1016/j.cej.2025.159320

18. Li Chen, Yunrong Li, Xuanxuan Zhang, Lixin Ma, Cheng Zhang, Huanhuan chen. (2025) A one-two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcers. Materials Today Bio. https://doi.org/10.1016/j.mtbio.2025.101548

19. Li Chen, Mengyi Zhan, Li Zhang, Zhuohang Xiong, Chi Zhang, Xuanxuan Zhang, Zhengyang Yang, Lixin Ma, Yibin Cheng, Huanhuan Chen. (2025) Dual-layer microneedles for immunomodulation and infection-responsive therapy in diabetic foot ulcers. Materials Today Bio. https://doi.org/10.1016/j.mtbio.2025.102490

20. Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, and Shanshan Li. (2025) Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6. Advanced Science. https://doi.org/10.1002/advs.202508525

21. Suqin Zhang, Meng Li, Jingyi Zeng, Songli Zhou, Feifan Yue, Zhaoyi Chen, Lixin Ma, Yang Wang, Fei Wang, Jingwen Luo. (2025) Somatostatin receptor-targeted polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic hepatocellular carcinoma therapy. Journal of Nanobiotechnology. https://doi.org/10.1186/s12951-025-03214-3

22. Zhongwei Zhang, Julin Chen, Ying Wang, Aitao Li. (2025) Biocatalytic conversion of caprolactam to 1, 6-hexanediamine: A novel route for nylon monomer production. ACS Catalysis. https://doi.org/10.1021/acscatal.5c05397

23. Huili Yu, Lei Hu, Xin Ruan, Xiaogang Peng, Pan Xiao, Ningjia Ao, Peng Chen, Chao Yang, Shu-Ming Li, Zhiyong Guo, Aitao Li. (2025) Rational mining and engineering of unique P450 enzymes enable production of diverse dimeric tryptophan-containing diketopiperazine alkaloids. ACS Catalysis. https://doi.org/10.1021/acscatal.5c06701

24. Qingyuan Jiang, Shuqi Jin, Zhichao Qin2, Junqi Zhang, Ruyi He, Zhuo Chen, Bin Qiao, Jie Qiao, Yi Liu. (2025) CRISPR/Cas12a DTR system: a topology-guided Cas12a assay for specific dual detection of RNA and DNA targets. Nucleic Acids Research. https://doi.org/10.1093/nar/gkaf893

25. Junqi Zhang, Mengjia Zhua, Hongbin Yan, Jie Qiao, Yi Liu. (2025) Split CRISPR/Cas systems: Pioneering solutions for molecular diagnostics challenges. Biosensors & Bioelectronics. https://doi.org/10.1016/j.bios.2025.118177

26. Guangbo Yan, Xia Li, Longyu Wang, Fei Wang, Siyuan Lv, Xiaolan Yu, Zhongchen Li, Jiakai Cui, Baotong Sun, Jia Hou, Wenqiang Li, Xiaochen Xie, Shuai Zhao, Zhiwei Zhang, Wanping Chen, Yanhong Peng, Yang Liu, Lixin Ma. (2025) In vitro programmable DNA cleavage by a eukaryotic Argonaute. Nucleic Acids Research. https://doi.org/10.1093/nar/gkaf561

27. Meng Li, Songli Zhou, Suqin Zhang, Xingyu Xie, Junqi Nie, Qi Wang, Lixin Ma, Yibin Cheng, Jingwen Luo. (2025) Transdermal delivery of CRISPR/Cas9-mediated melanoma gene therapy via polyamines-modified thermosensitive hydrogels. Journal of Nanobiotechnology. https://doi.org/10.1186/s12951-025-03523-7

28. Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang. (2025) A human engineered heart tissue-derived lipotoxic diabetic cardiomyopathy model revealed early benefits of empagliflozin. Advanced Science. https://doi.org/10.1002/advs.202503173

29. Longyu Wang, Xiaochen Xie, Fuyong Huang, Qiang Wei, Tianxin Cai, Na Yu, Shi Chen, Fei Wang, Wanping Chen, Chin-Yu Chen, Chunhua Li, Lixin Ma. (2025) An engineered PfAgo with wide catalytic temperature range and substrate spectrum. Advanced Science. https://doi.org/10.1002/advs.202416631

30. Wenjing Dai, Qi Yu, Rui Ma, Zhu Zheng, Lingling Hong, Yuqing Qi, Fei He, Min Wang, Feng Ge, Xilan Yu, Shanshan Li. (2025) PKA plays a conserved role in regulating gene expression and metabolic adaptation by phosphorylating Rpd3/HDAC1. Nature Communications. https://doi.org/10.1038/s41467-025-59064-y

31. Yan Li, Xuelian Guo, Jiayi Song, Kun Xu, Tian Qin, Xianhua Zhang, Zhaojian Song , Yuchi He, Biaoming Zhang, Haitao Zhang, Haitao Li, Wenya Yuan. (2025) OsSPL14 and OsNF-YB9/YC8-12 subunits cooperate to enhance grain appearance quality through promotingWaxyandPDIL1-1expression in rice. Plant Communications. https://doi.org/10.1016/j.xplc.2025.101348

32. Renyuan Deng, Xiangmei Liu, Jin Huang, Yi Wang, Dafu Chen, Chaofeng Wang,Khin Wee Lai, Congyang Mao, Guangrong Qian, Yufeng Zheng, and Shuilin Wu. (2025) The lattice defects of nanofilm introduced by N doping promotes radical oxygen species production for rapid photocatalytic elimination of contact infection. Advanced Functional Materials. https://doi.org/10.1002/adfm.202500256

33. Wenxue Jiang, Miao Wu, Zhou Gong, Linhua Han, Xiaoqi Cheng, Xiaoqin Tang, Xiaolong Yu, Xu Dong, Yibin Cheng, Lixin Ma, Qiong Xing. (2025) Structure-guided engineering of a Rieske-type aromatic dioxygenase for enhanced consumption of 3-phenylpropionic acid in Escherichia coli. Journal of Hazardous Materials. https://doi.org/10.1016/j.jhazmat.2025.137954

34. Xu Dong, Manli Xu, Miao Wu, Ying Wang, Xiaoqi Cheng, Wenxue Jiang, Dule Zheng, Ahmed Habiba Omar, Yibin Cheng , Aitao Li , Lixin Ma , Qiong Xing. (2025) Structural and catalytic insights into MhpB: A dioxygenase enzyme for degrading catecholic pollutants. Journal of Hazardous Materials. https://doi.org/10.1016/j.jhazmat.2025.137431

35. Xiaolong Zhang, Bin Feng, Yu Wang, Tingting Mu, Ming Zheng, Changbin Gao, Biaoming Zhang, Yan Li, Haitao Zhang, Wenya Yuan, Wei Hua, Haitao Li. (2025) Targeted disruption of five Bna.BRC1 homologs in rapeseed generates a highly branched germplasm for its multifunctional utilization. Plant Communications. https:/doi.org/10.1016/j.xplc.2025.101319

36. Feng Wang, Haijiang Xu, Chendi Zhang, Jialin Xue, Zhuang Li. (2025) Target DNA-induced filament formation and nuclease activation of SPARDA complex. Cell Research. https://doi.org/10.1038/s41422-025-01100-z

37. Huanhuan Qi, Jing Wang Xin Wang, Kun Liang, Meicheng Ke, Xueqing Zheng, Wenbin Tang, Ziyun Chen, Yinggen Ke, Pingfang Yang, Fazhan Qiu, Feng Yu. (2025) ZmEREB180 modulates waterlogging tolerance in maize by regulating root development and antioxidant gene expression. Plant Biotechnology Journal. https://doi.org/10.1111/pbi.70030

38. Linliang Zhang, Yali Qin, Mingzhou Chen. (2025) Flavivirus NS2A orchestrates reticulophagy to enhance viral pathogenicity. Autophagy. https://doi.org/10.1080/15548627.2025.2457112

39. Lixin Kang, Haoran Li, Kexin Lin, Shen Hu, Song Liu, Yuben Qiao, Ying Wang, Aitao Li. (2025) Regioselectivity switching in CYP107Pdh-Catalyzed VD3 hydroxylation: A structure-guided approach to improve calcidiol production. ACS Catalysis. https://doi.org/10.1021/acscatal.5c00444

40. Di Deng, Zhihui Jiang, Lixin Kang, Langxing Liao, Xiaodong Zhang, Yuben Qiao, Yang Zhou, Liulin Yang, Binju Wang, Aitao Li. (2025) An efficient catalytic route in haem peroxygenases mediated by O2/small-molecule reductant pairs for sustainable applications. Nature Catalysis. https://doi.org/10.1038/s41929-024-01281-7

41. Yunyun Yang, Yanling Li, Licheng Yao, Kexiang Dai, Xiaolong Fu, Aoyue Ge, Jian-Wen Huang, Rey-Ting Guo, Chun-Chi Chen. (2025) Structural insights into the N–N bond-formation mechanism of the heme-dependent piperazate synthase KtzT. ACS Catalysis. https://doi.org/10.1021/acscatal.4c06124

42. Siyu Li, Jian-Wen Huang, Jian Min, Hao Li, Meidan Ning, Shuyu Zhou, Yu Yang, Chun-Chi Chen, Rey-Ting Guo. (2025) Molecular insights into a distinct class of terpenoid cyclases. Nature Communications. https://doi.org/10.1038/s41467-024-55717-6

43. Shipeng Li, Xuanhao Zhang, Haodong Huang, Mou Yin, Matthew A. Jenks, Dylan K. Kosma, Pingfang Yang, Xianpeng Yang, Huayan Zhao, Shiyou Lü. (2025) Deciphering the core shunt mechanism in Arabidopsis cuticular wax biosynthesis and its role in plant environmental adaptation. Nature Plants. https://doi.org/10.1038/s41477-024-01892-9

44. Yuxin Zhang, Chengjie Tu, Jianyang Bai, Xiayu Li, Ziyue Sun, Letian Xu. (2025) Metabolic enhancement contributed by horizontal gene transfer is essential for dietary specialization in leaf beetles. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.2415717122

45. Zhiwei Zhang , Jinyue Wang, Tongyu Guo, Xiaolan Yu, Fei Wang, Hang Zhang, Yang Liu, Wenqiang Li , Yibin Cheng, Yanhong Peng, Guangbo Yan , Jiakai Cui, Lixin Ma. (2025) Argonaute-mediated RNA editing selectively repairs point mutations. Nucleic Acids Research. https://doi.org/10.1093/nar/gkaf1403

46. Zhihua Liu, Dapeng Xie, Stephen X. Zhang, Wenji Cai, Hao Zhou, Dragana Rogulja. (2025). Behavioral adaptation to warm conditions via Lim1-mediated acceleration of neuronal clocks. Nature Neuroscience. https://doi.org/10.1038/s41593-025-02139-2

47. Xiaoqi Cheng, Fangfang Zhang, Xu Dong, Xin Wang, Wenxue Jiang, Lixin Ma, Qiong Xing. (2025) Ultraweak interactions drive cap-mediated positioning and elongation of the bacterial flagellar filament. Nature Communications. https://doi.org/10.1038/s41467-025-67887-y.

48. Cuiyun Zhou, Feng Jiang, Wanping Chen, Sam R. Nugen, Chenxi Huang. (2025) Synthetic biology meets diagnostics: Engineering biosensing platforms for rapid and accurate pathogen and viral detection. Biosensors and Bioelectronics, 290, 117946.https://doi.org/10.1016/j.bios.2025.117946.

49. Ming Zixin, Zhou Menghan, Liu Xi, Guan Peng, Nugen Sam R, Menghwar Harish, Huang Chenxi, Wang Xiaohong. (2025). Fusing bacteriophage specificity with MOF nanozyme catalysis to construct an AI-enhanced platform for simultaneous pathogen detection and eradication. Chemical Engineering Journal. https://doi.org/10.1016/j.cej.2025.170578.

50. Qin Gong, Bo Song, Rong Zhao, Ruihua Ma, Danging Wang, Xiujuan Qin, Yao Li, Wanping Chen, Linxin Ma, Harish Menghwar, Chenxi Huang, and Qingin Ma. (2025) Bioluminescent-reporter phagosensor for quantitative detection of viable Escherichia coli in water. Water Research. https://doi.org/10.1016/j.watres.2025.124151.

51. Yuhong Qiu, Wanping Chen, Lixin Ma, Chenxi Huang.（2025）AI-guided Design of Metal-Organic Frameworks and Integrated Sensing Platforms for Food Safety Intelligent Detection. Coordination Chemistry Reviews. https://doi.org/10.1016/j.ccr.2025.217506.