一、基本情况
杨云云，博士，副教授，博士生导师
电子邮件：yang_yy(at)hubu.edu.cn
研究方向：主要结合免疫学、结构生物学、生物化学等手段研究：（1）疾病相关重要蛋白质的结构和分子机制；（2）抗肿瘤天然产物生成过程中的酶促反应机制；（3）重要工业酶的结构和催化机制。以第一和通讯作者（含共同）在Nature、Immunity、Angew.Chem.Int.Ed.、ACS Catalysis (四篇)等国际高水平期刊发表SCI文章10篇，授权国内外专利5项。
二、教育背景
2016–2019 清华大学，博士
三、工作经历
2020至今 太阳成tyc33455cc，博士后、副教授
四、主持科研项目
1. 国家重点专项青年项目，项目骨干
2. 国家自然科学基金面上项目，主持
3. 国家自然科学基金青年项目，主持
4. 湖北省人才项目，主持
5. 中国博士后特别资助，主持
6. 中国博士后面上项目，主持
7. 湖北省博士后创新研究岗位，主持
五、代表性论文（#第一作者; *通讯作者）
(1) Yang, Y.#*, Li, Y.#, Yao, L.#, Dai, K., Fu, X., Ge, A., Huang, J.-W., Guo, R.-T.*, Chen, C.-C.* (2025). Structural Insights into the N–N Bond-Formation Mechanism of the Heme-Dependent Piperazate Synthase KtzT. ACS Catalysis 15, 1265–1273. (IF=11.3，一区)
(2) Li, Y.#, Yang, Y.#, Zhang, M., Yue, X., Guo, R.-T.*, Huang, Z.*, Chen, F.* (2025). Mutagenesis of a Single Site Inverts the Stereopreference of Imine Reductase. ACS Catalysis 15, 2192-2199. (IF=11.3，一区)
(3) Liu, C., Yi, S., Zhang, M., Chen, C.-C., Liu, Y., Zhang, Z., Guo, R.-T.*, Yang, Y.* (2025) Molecular Glue Binding Behavior of Phosphoantigens to Alpaca Butyrophilins. JBC, 301, 108555. (二区)
(4) Yuan, L.#, Ma, X.#, Yang, Y.#, Qu, Y., Li, X., Zhu, X., Ma, W., Duan, J., Xue, J., Yang, H., Huang, J.-W., Yi, S., Zhang, M., Cai, N., Zhang, L., Ding, Q., Lai, K., Liu, C., Zhang, L., Liu, X., Yao, Y., Zhou, S., Li, X., Shen, P., Chang, Q., Malwal, S. R., He, Y., Li, W., Chen, C., Chen, C.-C., Oldfield, E., Guo, R.-T.,* Zhang, Y.* (2023). Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells. Nature, 621, 840-848. (IF=64.8，一区)
(5) Yang, Y.#, Li, L.#, Yuan, L.#, Zhou, X.#, Duan, J., Xiao, H., Cai, N., Han, S., Ma, X., Liu, W., Chen, C. C., Wang, L., Li, X., Chen, J., Kang, N., Chen, J., Shen, Z., Malwal, S. R., Liu, W., Shi, Y., Oldfield, E.*, Guo, R. T.*, Zhang, Y.* (2019). A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation. Immunity 50, 1043-1053. (IF=31.745，一区)
(6) Chen, C. C.#, Hu, X.#, Tang, X.#, Yang, Y.#, Ko, T. P., Gao, J., Zheng, Y., Huang, J. W., Yu, Z., Li, L., Han, S., Cai, N., Zhang, Y.*, Liu, W.*, Guo, R. T.* (2018). The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement. Angewandte Chemie International Edition 57, 15060-15064. (IF=15.336，一区)
(7) Malwal, S. R.#, Gao, J.#, Hu, X.#, Yang, Y.#, Liu, W., Huang J. W., Ko, T. P., Li, L., Chen, C. C., O’Dowd, B., Khade, R. L., Zhang, Y., Zhang, Y.*, Oldfield, E.*, Guo, R. T.* (2018). Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes. ACS Catalysis 8, 4299-4312. (IF=13.084，一区)
(8) Zeng, W.#, Li, X.#, Yang, Y.#, Min, J.#, Huang J. W., Liu, W., Niu, D., Yang, X., Han, X., Zhang, L., Dai, L., Chen, C. C.*, Guo, R. T.* (2022).Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy. ACS Catalysis 12, 3033-3040. (IF=13.084，一区)
(9) Yang, Y.#, Ko, T. P.#, Chen, C. C.#, Huang, G., Zheng, Y., Liu, W., Wang, I., Ho, M., Hsu, S., O'Dowd, B., Huff, H., Huang, C. H., Docampo, R., Oldfield, E.*, Guo, R. T.* (2016). Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Antiparasitic Drug Targets. ACS Chemical Biology 11, 1362−1371. (二区)
(10) Wang, J.#, Chen, C. C.#, Yang, Y.#, Liu, W., Ko, T. P., Shang, N., Hu, X., Xie, Y., Huang, J. W., Zhang, Y.*, Guo, R. T.* (2018). Structural Insight into a Novel Indole Prenyltransferase in Hapalindole-type Alkaloid Biosynthesis. Biochemical and Biophysical Research Communications 495, 1782-1788. (三区)
六、荣誉及奖励
（1）2021年获湖北省优秀博士后追踪计划
（2）2020年获得“清华大学优秀博士毕业生”
（3）2020年获得“清华大学优秀博士学位论文”
（4）2020年获得“启航奖”
（5）2019年获得“国家奖学金”
（6）2019年获得“卓越奖学金”
（7）2018年获得“光华奖学金”
